时 间：2013年11月28日（周四）下午4:00-5:30
地 点：丁家桥校区综合楼三楼半多媒体教室
讲座内容：
Problem-based learning in the medical curriculum: integration of basic sciences and clinics
Prof. Eleonore Köhler
Maastricht University
地 点：丁家桥校区综合楼三楼半多媒体教室
讲座内容：
Problem-based learning in the medical curriculum: integration of basic sciences and clinics
Prof. Eleonore Köhler
Maastricht University
Position: Programme coordinator Master Biomedical Sciences
Leo Köhler studied biology (Göttingen, Germany; Basle, Switzerland) and received her PhD in 1990 for the thesis titled: “Probing the substrate specificity of E. coli aspartate aminotransferase by site-directed mutagenesis”. Following a postdoc period in Hannover on Protein-DNA Interactions, she had two positions as senior researcher in Basle where she studied cardiac fibrosis and hepatoblastoma. In 2002, she joined a NUTRIM research group at Maastricht University as senior researcher. Her research focuses on Amino-acid metabolism in inflammatory diseases and development. She is co-promoter of 7 PhD students. Over the years she received national and EU grants for app. 900 k€.
Leo Köhler teaches histology and basic anatomy in many UM-curricula. Since 2006 she is acting head and since 2011 head of the department of Anatomy & Embryology. She was a member of the planning committee of the master Molecular Life Sciences and has been active as a lecturer, tutor, coach, block coordinator and member of the Educational committee within the programme. In 2008 she took over the programme coordination and became a member of the Management team BMW/MLS. In 2011 she has won the FHML Education price for her role in this programme.
Key publications
· Köhler E, M Seville, J Jager, I Fotheringham, M Hunter, M Edwards, JN Jansonius, and K Kirschner. Significant improvement to the catalytic properties of aspartate amino-transferase: role of hydrophobic and charged residues in the substrate binding pocket. Biochemistry, 1994. 33(1): p. 90-7.
· Köhler E, S Bertschin, T Woodtli, T Resink, and P Erne. Does aldosterone-induced cardiac fibrosis involve direct effects on cardiac fibroblasts? J Vasc Res, 1996. 33(4): p. 315-26.
· Roth M, O Eickelberg, E Köhler, P Erne, and LH Block. Ca2+ channel blockers modulate metabolism of collagens within the extracellular matrix. PNAS, 1996. 93(11): p. 5478-82.
· Schnater JM, E Bruder, S Bertschin, T Woodtli, C de Theije, T Pietsch, DC Aronson, D von Schweinitz, WH Lamers, and ES Köhler. Subcutaneous and intrahepatic growth of human hepatoblastoma in immunodeficient mice. J Hepatol, 2006. 45(3): p. 377-86.
· Köhler ES, S Sankaranarayanan, CJ van Ginneken, P van Dijk, JL Vermeulen, JM Ruijter, WH Lamers, and E Bruder. The human neonatal small intestine has the potential for arginine synthesis; developmental changes in the expression of arginine-synthesizing and -catabolizing enzymes. BMC Dev Biol, 2008. 8: p. 107.
· Marion VM, S Sankaranarayanan, C de Theije, P van Dijk, P Lindsey, MC Lamers, HP Harding, D Ron, WH Lamers and SE Köhler. Arginine deficiency causes runting in the suckling period by selectively activating the stress kinase GCN2. J Biol Chem 2011.
· Comhair T, Garcia Caraballo S, Dejong CH, Lamers WH, and SE Köhler. Dietary cholesterol, female gender and n-3 fatty acid deficiency are more important factors in the development of non-alcoholic fatty liver disease than the saturation index of the fat.Nutr Metab 2011. 8(1):4